Protein Kinase A (PKA)

8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator.

Dibutyryl-cAMP is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.

6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways.

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.