Membrane Transporters-Ion Channels

JT010 is a potent agonist of TRPA1 with an EC50 of 0.65 nM.

SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [3H]-kainate binding with an IC50 of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively.

(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).

(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.