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Membrane Transporters-Ion Channels
Membrane Transporters-Ion Channels
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intracellular Ca2+ handling modulator
Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.
Farampator has been investigated for its effect on AMPA receptors and researched for potential use in the treatment of schizophrenia and Alzheimer's Disease. It was found to improve short-term memory, but impaired episodic memory.
MRS1477 is a TRPV1 positive allosteric modulator.
GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM.
Branaplam (LMI070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
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