Melatonin Receptors

Melatonin is a endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2.

Prazosin HCl is an α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM).

Tasimelteon is a melatonin MT1 and MT2 receptor agonist.

Luzindole, also known as N-0774, and N-acetyl-2-benzyltryptamine, is a melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values are = 10-27 and 158-513 nM, respectively).