Metabotropic glutamate receptors (mGluR)

JNJ-40411813 is a novel mGluR2 PAM.

JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor.

VU0364289 is a novel N-aryl piperazine mGlu5 positive allosteric modulator.

DFMTI is an allosteric negative modulator of mGluR1 receptors.

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .