Apoptosis Inducers

Difopein, dimeric version of R18 peptide that binds to 14.3.3 proteins with high affinity.

SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells.

CHM 1 is a potent, selective antitumor agent in human hepatocellular carcinoma in vitro.

CFM 4, CARP-1 mimetic; interferes with CARP-1 binding to APC-2. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses cell growth in cancer cells.

ONC212 is a fluorinated-ONC201 analogue, shows preclinical efficacy in melanoma and hepatocellular-cancer models. ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib.

NUN82647, also known as QBS or 2-Amino-N-quinolin-8-yl-benzenesulfonamide, is an Inhibitor of cell cycle at G2 phase; apoptosis inducer.