Bcl-2 Family

BDA-366 selectively inhibits BCL2, converting it to a cell death inducer.

MIK665 (S-64315) is a special Mcl-1 inhibitor extracted from patent WO2016207225A1, compound Preparation 13, has an IC50 of 1.81 nM.

Mcl1-IN-2 is a selective Mcl-1 inhibitor.

Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 0.2 μM.

BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM respectively.

DT2216 is a potent and selective BCL-XL degrader based on PROTAC technology.