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Bcl-2 modulator
BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells. -
CRBN modulator
Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 of 60 nM.