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Product Information
Product Citation
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ROCK inhibitor
ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.- Delia Talpan, .et al. , Int J Mol Sci, 2023, Jan 11;24(2):1461 PMID: 36674976
- Nina Seidelmann, .et al. , J Cell Mol Med, 2021, Oct;25(20):9647-9659 PMID: 34486211
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ROCK2 inhibitor
ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM. -
ROCK inhibitor
Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008. -
MRTF pathway inhibitor
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression.