Shop By
Catalog No.
Product Name
Application
Product Information
Product Citation
-
DHFR inhibitor
NSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. - Aminopterin is an antineoplastic drug. It works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase.
- Nobuo Aikawa, .et al. , J Toxicol Sci, 2020, 45(4):187-199 PMID: 32238694
- Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.
-
DHFR inhibitor
Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.