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- Afegostat D-tartrate was an experimental drug for the treatment of certain forms of Gaucher's disease. The substance was used in form of the tartrate. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone.
- 3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor.
- Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has signi?cant α-glucosidase inhibitory activity.
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alpha-glucosidase/alpha-1,6-glucosidase inhibitor
N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of alpha-glucosidase and alpha-1,6-glucosidase (IC50s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown. -
α-glucosidase inhibitory activities
Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC50 of 1.4 mM.
