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TrxR1/CRM1 inhibitor
Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). -
co-inducer of heat shock proteins (HSP)
Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP).