Lipoxygenase

Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.

Edaravone is a free radical scavenger with diverse protective effects that inhibits production of reactive oxygen species, apoptosis and the lipoxygenase system.

Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase, 5-LOX) inhibitor.

Nordihydroguaiaretic acid is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo. Its analogs are in clinical development for use in refractory solid tumors.

CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 μM.