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Metabolism
PAI-1

PAI-1

Catalog No.

Product Name

Application

Product Information

Product Citation

A14190

Tiplaxtinin (PAI-039)

PAI-1 inhbitor

Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM.

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- Saijo A, .et al. , Cancer Lett, 2018, May 1;421:17-27 PMID: 29448000
A19369

TM5441

PAI-1 inhibitor

TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines.

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