PPAR

GW6471 is a PPARα antagonist, shown to completely inhibit GW409544-induced activation of PPARα.

NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively.

GW 6471 is a potent PPARα antagonist.