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MK-2206 2HCl
Catalog No.: A10003
AKT Inhibitor
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
Adooq Products cited in reputable paper
Adooq's MK-2206 2HCl has been cited by 19 publications
Yi-Ru Pan, .et al. , Int J Biol Sci , 2023, May 21;19(9):2772-2786 PMID: 37324940 Giorgio Caratti, .et al. , EMBO Rep , 2023, Feb 6;24(2):e55363 PMID: 36520372 Ming-Chun Hung, .et al. , Cell Biosci , 2022, 12: 122 PMID: 35918763 Yusuke Murase, .et al. , Oncol Rep , 2022, Apr;47(4):61 PMID: 35088890 Majid Momeny, .et al. , Life Sci , 2021, Dec 15;287:120100 PMID: 34715143 Ali Nasrollahzadeh, .et al. , Biochim Biophys Acta Mol Cell Res , 2021, Jun 26;1868(10):119087 PMID: 34182011 Rona Aviram, .et al. , PLoS Biol , 2021, Dec 30;19(12):e3001492 PMID: 34968386 Cristina Roselló-Busquets, .et al. , Front Mol Neurosci , 2020, 13: 56 PMID: 32317932 Dai-Chi Liu, .et al. , eNeuro , 2020, Mar 27;7(2):ENEURO.0438-19.2020 PMID: 32161037 Nishihama K, .et al. , Metabolism , 2018, May;82:88-99 PMID: 29366755 J Wei, .et al. , bioRxiv , 2018, 2018 Joo Sang Lee, .et al. , Nat Commun , 2018, 9: 2546 PMID: 29959327 Wan-Ting Hu, .et al. , Am J Cancer Res , 2018, 8(9): 1739-1751 PMID: 30323967 Angela M. Gocher, .et al. , J Biol Chem , 2017, Aug 25; 292(34): 14188-14204 PMID: 28634229 Kusuyama J, .et al. , Biochem J , 2017, Oct 5;474(20):3421-3437 PMID: 28887384 Pi-Lin Sung, .et al. , Oncotarget , 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408 Mikaël M. Martino, .et al. , Nat Commun , 2016, 7: 11051 PMID: 27001940 Dominik Schulz, .et al. , Am J Cancer Res , 2016, 6(9): 1963-1975 PMID: 27725902 Jewett KA, .et al. , J Neurochem. , 2015, Oct;135(2):226-33 PMID: 26250624
MK-2206 2HCl related products
Biological Activity
Discription
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
Targets
Solubility
In vitro (25°C)
DMSO
12 mg/mL (24.98 mM)
Water
Insoluble
Ethanol
Insoluble
In vivo
5% DMSO+40% PEG 300+5%Tween80+ 50%H2O
0.59 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
0.1 mM
20.82 mL
104.08 mL
208.16 mL
0.5 mM
4.16 mL
20.82 mL
41.63 mL
1 mM
2.08 mL
10.41 mL
20.82 mL
5 mM
0.42 mL
2.08 mL
4.16 mL
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
* Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1 V1 = C2 V2
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