Signaling Pathway
DNA alkylators are a class of compounds that can add alkyl groups (e.g., methyl or ethyl groups) to the DNA molecule, leading to DNA damage. This modification can result in mispairing or prevention of DNA replication, which can lead to cell death. Given their ability to damage DNA, alkylating agents are used as chemotherapy drugs to treat various cancers. However, their use can also be associated with significant side effects, as they can damage normal cells in addition to cancer cells. Popular examples of alkylating agents include cyclophosphamide, melphalan, and busulfan.
