DNA/RNA Synthesis

Lurbinectedin (PM01183) is a new DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.

N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic.