Progesterone Receptors

CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.

Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.

Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.

CRTh2 antagonist 1 is a CRTh2 antagonist with an IC50 of 89 nM.

MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.

QCC-374 is prostanoid agonist potentially for the treatment of pulmonary arterial hypertension.