Histone Methyltransferase

Entacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

Flopropione is a 5-HT1A receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor.

Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor.