Protein Tyrosine Phosphatase

Bakuchiol is an antioxidant inhibitor of protein tyrosine phosphatase 1B (PTP1B).

Alexidine is an alkyl bis(biguanide) antiseptic which has been used in mouthwashes to eliminate plaque forming microorganisms.

BVT 948 is a non-competitive PTP (protein tyrosine phosphatase) inhibitor.

NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1).

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively.

Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM.

SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM.