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  1. COX-1 and COX-2 inhibitor

    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
  2. COX-2 Inhibitor

    FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID.
  3. COX inhibitor

    Pamicogrel (KBT3022) is a cyclooxygenase (COX) inhibitor.

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