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Immunology & Inflammation
Immunology & Inflammation
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IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
PD-1-IN-1 is an inhibitor of programmed cell dealth-1 (PD-1) extracted from patent WO2015033299A1, compound example 4. PD-1-IN-1 can be used as immune modulator.
Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.
Aceneuramic acid is an immunomodulator potentially for treatment of hereditary inclusion body myopathy (HIBM).
NSC-23026 is a CXCR4 receptor modulator.
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
CXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM.
E6130 is an orally available and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.
human CX3CR1 receptor modulator
AZD8797 is an allosteric non-competitive and orally active modulator of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively.
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