Toll-like Receptors

Isatoribine is a novel guanosine analogue showing immunostimulatory activity both in vivo and in vitro.

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein.