Toll-like Receptors

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein.

MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity.