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LGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).
2 publications
Ricardo de Matos Simoes, .et al. , Nat Cancer , 2023, May;4(5):754-773 PMID: 37237081 Andrea L. Casillas, .et al. , Clin Cancer Res , 2018, Jan 1; 24(1): 169-180 PMID: 29084916
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM.
SEL24-B489 HCl is a potent, dual pan-PIM/FLT3 inhibitor.
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