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MLK inhibitor
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.- Elad Prinz, .et al. , Mol Biol Cell, 2018, Oct 1; 29(20): 2470-2480 PMID: 30091641
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MLKL inhibitor
Necrosulfonamide is a pharmacological inhibitor of MLKL with IC50 values of 124 nM in human HT-29.