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- Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling.
- Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.
- Ji Hyung Jun, .et al. , Sci Adv, 2021, May 14;7(20) PMID: 33990337
- Jun JH, .et al. , Nat Plants, 2018, Dec;4(12):1034-1043 PMID: 30478357
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CDK336 Inhibitor
Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities. - Daurinoline is an alkaloid from the rhizomes of Menispermum canadense and Menispermum dauricum and from Phaeanthus vietnamensis.
- Budesonide is a glucocorticoid steroid for the treatment of asthma and non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. In addition, it is used for Crohn's disease (inflammatory bowel disease).
- Cyclosporin C is a highly lipophilic cyclic peptide natural product, a member of the cyclosporin series of antifungal and immunosuppresive compounds - Cyclosporin A and B. The cyclosporins bind the cyclophilin intracellular proteins, highly conserved proteins involved in cis-trans isomerization of peptidyl-prolyl bonds and protein folding.
- Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
- Trichodesmine is a pyrrolizidine alkaloid that has neurotoxic effects and is naturally found in Crotolaria argyptiaca, a shrub plant that is native to the south eastern desert of Egypt.
- Rashmi Rawat, .et al. , Food Chemistry Advances, 2022, 1: 100092
- Nitrarine 2HCl is a hypotensive? spasmolytic? coronary dilator? sedative in experimental arrhythmias. in experimental arrhythmias in the cat? caused by calcium chloride? Aconitine and electric cardiac stimulation? Nitrarine dihydrochloride presents a hypotensive? spasmolytic? coronary dilating and sedative action. Its antiarrhythmic properties are due to its stabilizating effects on the membrane and its coronary dilating action. Nitrarine dihydrochloride is 3-4 times as potent as Novocainamide and Quinidine? and the duration of its effect is 2-5 times longer than that of these products.
- Mitragynine is an indole alkaloid from the plant Mitragyna speciosa. It has stimulatory, antinociceptive, and opiate-like effects, acting through noradrenergic, serotonergic, and opioid receptors
- Desacetylnimbin is a new limonoid from Arisaema decipiens, a traditional antitumor herb.
- Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 uM in Raji cells).
- Protostemonine (PSN) is the main anti-inflammatory alkaloid extracted from the roots of Stemona sessilifolia (known as ?€?Baibu?€? in traditional Chinese medicine).
- Ophiopogonin D is a new phenylpropanoid glycoside from Ophiopogon japonicus Ker-Gawl.
- (+)-Piresil-4-O-beta-D-glucopyraside was extracted from Forsythia Suspensa fruit.
- Kaempferol 3-O-glucoside (astragalin) is the 3-glucoside of the flavonol kaempferol, a type of polyphenol.
- Anemarsaponin E was extracted from rhizoma anemarrhenae root barks and barks.
- Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylation.
- Dehydrocorydaline is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang.
- Byakangelicol, isolated from Angelica dahurica, inhibits both the activity and induction of cyclooxygenase-2 in human pulmonary epithelial cells.
- Paederosidic acid methyl ester, a chemical compound isolated from the n-butanol fraction of Paederia scandens.
- Emodin-8-glucoside is a glucoside metabolite of emodin. Emodin is a potent Lck inhibitor.
- Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant a-Synuclein and Huntingtin in PC-12 Cells.
- Kaempferol-3-O-rutinoside is a bitter-tasting flavonol glycoside. It can be isolated from the rhizomes of the fern Selliguea feei.
- Licochalcone C was synthesized from commercially available 2,4-dihydroxybenzaldehde by using regioselective Al2O3-mediated C-prenylation followed by conventional Claisen-Schmidt condensation in basic condition.
- Licochalcone B, which belongs to the retrochalcone family, is isolated from the roots of Chinese licorice.
- Diosmetin-7-O-beta-D-glucopyranoside, extracted from Chrysanthemum dried flowers.
- Quercetin-7-O-beta-D-glucopyranoside, extracted from Sophora flavescens Ait.
- Isorhamnetin-3-O-beta-D-Glucoside, extracted from dried whole herb of Filifolium Kitam. Filifolium sibiricum (L.) Kitam..
- Purpureaside C is a phenolic glycoside and has significant proinflammatory action.
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flavonoid
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.