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Catalog No.
Product Name
Application
Product Information
Product Citation
Nicotinic (α7) Receptor Modulator
PNU-120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors.
A-867744 is a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
NS 1738 is a α7 positive allosteric modulator.
2 publications
Spencer R. Pierce, .et al. , Biomolecules , 2023, 13(4), 698 PMID: 37189445 Hugo R Arias, .et al. , Br J Pharmacol , 2022, Sep 9 PMID: 36082615
α7 nAChR-positive allosteric modulator
CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs.
Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity.
α7 nAChR negative alteration modulator
BNC210 (H-Ile-Trp-OH; IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.
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