Purinergic (P2Y) Receptors

Cangrelor Tetrasodium is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. Unlike clopidogrel (Plavix), which is a prodrug, cangrelor is an active drug not requiring metabolic conversion.

Vicagrel, an acetate derivative of Clopidogrel, is a P2Y12 platelet inhibitor potentially for the treatment of thrombosis.

Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent.

Prasugrel (PCR 4099) Maleic acid is a platelet inhibitor with IC50 value of 1.8 μM.