Protein Tyrosine Kinases

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  1. PNP inhibitor

    CI 972 is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent.
  2. Transmethylation Inhibitor

    SIBA selectively inhibits spermine synthase, IC50=8 uM.
  3. PNP inhibitor

    Forodesine(BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells.

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