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Protein Tyrosine Kinases
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cNIIIB nucleotidase inhibitor
7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8????7.5??M.
CI 972 is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent.
Transmethylation Inhibitor
SIBA selectively inhibits spermine synthase, IC50=8 uM.
Forodesine(BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells.
Forodesine hydrochloride (BCX-1777) is a highly potent and specific purine nucleoside phosphorylase (PNP) inhibitor.
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Inhibitor
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Nucleoside Antimetabolite/Analog
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