ITK

GSK-2250665A is a Itk inhibitor with pKi = 9.2, it Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC50 values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.

CTA 056 is a potent and selective ITK inhibitor (interleukin-2-inducible T-cell kinase inhibitor).