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SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively.
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.
1 publications
Kevin Bohm, .et al. , Arch Pharm (Weinheim) , 2023, Jul;356(7):e2200661 PMID: 37196427
GNE-6776 is a selective USP7 inhibitor.
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