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Vandetanib (ZD6474)


VEGFR inhibitor

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Catalog No. A10963

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Vandetanib 25mg A10963-25

Regular Price: €57.00

Special Price: €51.30

Vandetanib 50mg A10963-50

Regular Price: €95.00

Special Price: €85.50

Vandetanib 100mg A10963-100

Regular Price: €190.00

Special Price: €171.00

Vandetanib 500mg A10963-500

Regular Price: €427.50

Special Price: €384.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.

Vandetanib (ZD6474)

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Publications citing Adooq Products
Vandetanib (ZD6474) Citations (5)
  • Rintaro Sogawa, .et al. Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib, JPA, 2018, in Press
  • Park K, .et al. Vascular endothelial growth factor receptor 1 (VEGFR1) tyrosine kinase signaling facilitates granulation tissue formation with recruitment of VEGFR1+ cells from bone marrow, Anat Sci Int, 2018, Jun;93(3):372-383 PMID: 29256114
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Park K, .et al. Vascular endothelial growth factor receptor-1 (VEGFR-1) signaling enhances angiogenesis in a surgical sponge model, Biomed Pharmacother, 2016, Mar;78:140-149 PMID: 26898435

Chemical Information

Catalog Num A10963
Actions Inhibitor
M. Wt 475.4
Formula C22H24BrFN4O2
Solubility DMSO>4mg/mL Water<1mg/mL Ethanol>3mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 443913-73-3
Synonyms ZD6474

Biological Activity

Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.
VEGFR2 (Cell-free assay)
40 nM


Solubility (25°C)* In vitro DMSO 4 mg/mL (8.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.03 mL 105.17 mL 210.35mL
0.5 mM 4.21 mL 21.03 mL 42.07 mL
1 mM 2.1 mL 10.52 mL 21.03 mL
5 mM 0.42 mL 2.1 mL 4.21 mL

*The above data is based on the productmolecular weight 475.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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