Vandetanib (ZD6474)

Catalog No.: A10963

VEGFR inhibitor

Vandetanib (ZD6474)

Vandetanib (ZD6474) Chemical Structure

CAS NO. 443913-73-3

Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.

Availability: In stock

Package Price Qty
25 mg

Regular Price: $60.00

Special Price $48.00

50 mg

Regular Price: $100.00

Special Price $80.00

100 mg

Regular Price: $200.00

Special Price $160.00

500 mg

Regular Price: $450.00

Special Price $360.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.
Targets
VEGFR2 (Cell-free assay)
40 nM
In vitro DMSO 4 mg/mL (8.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.03 mL 105.17 mL 210.35 mL
0.5 mM 4.21 mL 21.03 mL 42.07 mL
1 mM 2.1 mL 10.52 mL 21.03 mL
5 mM 0.42 mL 2.1 mL 4.21 mL

*The above data is based on the productmolecular weight 475.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10963
Actions Inhibitor
M. Wt 475.4
Formula C22H24BrFN4O2
Solubility DMSO>4mg/mL Water<1mg/mL Ethanol>3mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 443913-73-3
Synonyms ZD6474
SMILES CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC

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