You have no items in your shopping cart.
Publications citing Adooq Products
Vandetanib (ZD6474) Citations (5)
- Rintaro Sogawa, .et al. Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib, JPA, 2018, in Press
- Park K, .et al. Vascular endothelial growth factor receptor 1 (VEGFR1) tyrosine kinase signaling facilitates granulation tissue formation with recruitment of VEGFR1+ cells from bone marrow, Anat Sci Int, 2018, Jun;93(3):372-383 PMID: 29256114
- Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
- Park K, .et al. Vascular endothelial growth factor receptor-1 (VEGFR-1) signaling enhances angiogenesis in a surgical sponge model, Biomed Pharmacother, 2016, Mar;78:140-149 PMID: 26898435
Chemical Information
| Catalog Num | A10963 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 475.4 |
| Formula | C22H24BrFN4O2 |
| Solubility | DMSO>4mg/mL Water<1mg/mL Ethanol>3mg/mL |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 443913-73-3 |
| Synonyms | ZD6474 |
| SMILES | CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC |
Description |
Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C)* | In vitro | DMSO | 4 mg/mL (8.41 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.03 mL | 105.17 mL | 210.35mL |
| 0.5 mM | 4.21 mL | 21.03 mL | 42.07 mL |
| 1 mM | 2.1 mL | 10.52 mL | 21.03 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.21 mL |
*The above data is based on the productmolecular weight 475.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
€42.75
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tu ...
Special Price Starting at: €42.75
Special Price Starting at:
€190.00
Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. ...
Special Price Starting at: €190.00
Special Price Starting at:
€59.85
SU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. ...
Special Price Starting at: €59.85
Special Price Starting at:
€34.20
BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR. ...
Special Price Starting at: €34.20
Special Price Starting at:
€42.75
Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays. ...
Special Price Starting at: €42.75
Special Price Starting at:
€209.00
TG 100572 is VEGFR2 and Src kinase inhibitor. ...
Special Price Starting at: €209.00
Special Price Starting at:
€34.20
Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and ...
Special Price Starting at: €34.20
Special Price Starting at:
€128.25
(-)-Catechin gallate is an antioxidant constituent of green tea. At uM concentrations, inhibits VEGF-induced tyrosine phosphorylation. ...
Special Price Starting at: €128.25
Special Price Starting at:
€102.60
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers. ...
Special Price Starting at: €102.60
Special Price Starting at:
€59.85
Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the ...
Special Price Starting at: €59.85
Special Price Starting at:
€51.30
R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor ty ...
Special Price Starting at: €51.30
Special Price Starting at:
€34.20
Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
...
Special Price Starting at: €34.20
Special Price Starting at:
€85.50
ZM 323881 is a potent and selective inhibitor of the kinase activity of the human vascular endothelial growth factor receptor 2 (VEGFR2/KDR). ...
Special Price Starting at: €85.50
Special Price Starting at:
€95.00
BMS-817378 is a novel prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833. ...
Special Price Starting at: €95.00
Special Price Starting at:
€51.30
XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. ...
Special Price Starting at: €51.30
Special Price Starting at:
€28.50
Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors. ...
Special Price Starting at: €28.50
Special Price Starting at:
€85.50
SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like ty ...
Special Price Starting at: €85.50
Special Price Starting at:
€85.50
Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling. ...
Special Price Starting at: €85.50
Special Price Starting at:
€55.58
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. ...
Special Price Starting at: €55.58
Special Price Starting at:
€95.00
ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) with IC50 value of 2 nM. ...
Special Price Starting at: €95.00
Special Price Starting at:
€51.30
Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. ...
Special Price Starting at: €51.30
Special Price Starting at:
€85.50
Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine ki ...
Special Price Starting at: €85.50
Special Price Starting at:
€190.00
CP-547632 is a novel, potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ...
Special Price Starting at: €190.00
Special Price Starting at:
€42.75
Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activit ...
Special Price Starting at: €42.75
Special Price Starting at:
€76.00
KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive ...
Special Price Starting at: €76.00
Special Price Starting at:
€76.00
TPT-260 is a thiophene thiourea derivative. ...
Special Price Starting at: €76.00
Special Price Starting at:
€42.75
Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibitor. ...
Special Price Starting at: €42.75
Special Price Starting at:
€94.05
E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinas ...
Special Price Starting at: €94.05
Special Price Starting at:
€34.20
Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors. ...
Special Price Starting at: €34.20
Special Price Starting at:
€42.75
E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases. ...
Special Price Starting at: €42.75
Keywords:buy Vandetanib (ZD6474) | Vandetanib (ZD6474) Supplier | purchase Vandetanib (ZD6474) | Vandetanib (ZD6474) cost | Vandetanib (ZD6474) manufacturer | order Vandetanib (ZD6474) | Vandetanib (ZD6474) distributor | buy 443913-73-3| 443913-73-3 Supplier | purchase 443913-73-3 | 443913-73-3 cost | 443913-73-3 manufacturer | order 443913-73-3 | 443913-73-3 distributor
We Using Safe Payments:
