Catalog No.
Product Name
Application
Product Information
Citations
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14-3-3 protein Inhibitor
Difopein, dimeric version of R18 peptide that binds to 14.3.3 proteins with high affinity.- William J Stone, .et al. , J Neurochem, 2025, Sep;169(9):e70228 PMID: 40931680
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Apoptosis inducer
LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.- Yingzheng Xu, .et al. , JCI Insight, 2024, Jun 13:e174746 PMID: 38869957
- Ting TC, .et al. , Cell Rep, 2019, Nov 5;29(6):1499-1510.e6 PMID: 31693891
- Ting Han, .et al. , Science, 2017, Apr 28;356(6336). pii: eaal3755 PMID: 28302793
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Apoptosis Inducer
Andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent. -
apoptosis inducer
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. - Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis.
- Darinaparsin, also know as ZIO-101 and SP-02, is a small-molecule organic arsenical with potential antineoplastic activity.
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inhibitor of tubulin polymerization
4-Oxo-4-HPR is an inhibitor of tubulin polymerization, inducing marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. It is also a fenretinide metabolite. -
Apoptosis Inducer
epi-Eriocalyxin A is a diterpenoid compound that serves as an apoptosis inducer in colon cancer cells. It effectively inhibits the activation of ERK1/2 and JNK pathways, leading to the suppression of Bcl-2 expression. This compound is valuable for research focused on cancer treatment and the mechanisms of apoptosis. -
Apoptosis Inducer
Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms. -
Apoptosis Inducer
Dimethyl tetrasulfide (1,4-Dimethyltetrasulfane) is an apoptosis inducer that specifically targets leukemia cells. It demonstrates cytotoxic effects by promoting the production of intracellular reactive oxygen species (ROS) and activating the caspase-3 enzyme. This compound is valuable for research into cancer therapies, particularly in the context of leukemia. -
Apoptosis Inducer
9-cis-Canthaxanthin is a carotenoid recognized for its pro-apoptotic properties, particularly in THP-1 macrophage cells. This compound induces apoptosis by enhancing the activity of caspase-3 and caspase-8, making it a valuable tool for studying apoptosis pathways and cellular responses in various research applications. -
Apoptosis Inducer
Euptox A (9-Oxo-10, 11-dehydroageraphorone) is a potent apoptosis inducer derived from the cadenine sesquiterpene found in Eupatorium adenophorum. It enhances the expression of apoptotic proteases, particularly caspase-10, in HeLa cells, leading to increased apoptotic activity. This compound is valuable for research into apoptosis mechanisms and potential therapeutic applications in cancer treatment. -
Apoptosis Inducer
MT-21 is an apoptosis inducer that functions as an inhibitor of adenine nucleotide translocase. It triggers apoptosis by activating c-Jun N-terminal kinase (JNK) through the Krs/MST signaling pathway and facilitates the activation of caspase-3 via caspase-9. Additionally, MT-21 promotes the release of cytochrome c from mitochondria, making it a valuable reagent for investigating tumor biology and apoptotic mechanisms in cancer research. -
Apoptosis Inducer
SM1044 is a dihydroartemisinin (DHA) dimer that serves as an apoptosis inducer. It activates caspase pathways to effectively trigger apoptosis in RL95-2 and KLE cancer cell lines. Additionally, SM1044 demonstrates potent antiproliferative activity, with IC50 values below 3.6 μM across multiple cancer cell lines, including HEC-50, HEC-1-A, HEC-1-B, and AN3CA. Furthermore, SM1044 has been shown to inhibit tumor growth in RL95-2 xenograft mouse models, highlighting its potential utility in cancer research. -
Apoptosis Inducer
Ly101-4B is an apoptosis inducer that primarily targets the regulation of key proteins involved in cell survival and proliferation. It exhibits significant antiproliferative and cytotoxic effects by reducing HSF1 expression and inhibiting microRNA-214 synthesis, leading to the downregulation of HSP27, HSP70, and HSP90. Additionally, Ly101-4B activates caspase 3/7-mediated apoptosis by impairing DNA synthesis and disrupting the cell cycle at the G1/S phase transition, while sparing RNA synthesis and avoiding necrosis. This compound is particularly effective against pancreatic ductal adenocarcinoma cells with distinct genotypes and levels of E2F dependence, making it valuable for research in epithelial ovarian cancer and pancreatic ductal adenocarcinoma. -
Apoptosis Inducer
Antitumor agent-72 is a potent apoptosis inducer targeting key apoptotic pathways. This compound effectively activates caspase-3 and induces PARP cleavage, leading to significant anticancer activity. Antitumor agent-72 is suitable for studies related to cancer research and the exploration of apoptosis mechanisms. -
Apoptosis Inducer
3-Methoxy-9H-Carbazole is a potent apoptosis inducer that primarily targets caspase-3 activity. This compound enhances the generation of reactive oxygen species, leading to the inhibition of cancer cell proliferation and the initiation of apoptotic pathways. Its biological activity makes it a valuable tool for research into cancer mechanisms and apoptosis-related studies. -
Apoptosis Inducer
cRIPGBM is a proapoptotic derivative of RIPGBM that selectively induces apoptosis in glioblastoma (GBM) cancer stem cells by targeting receptor-interacting protein kinase 2 (RIPK2). It demonstrates an EC50 of 68 nM in GBM-1 cells, making it a valuable tool for studying apoptosis mechanisms in cancer research. This compound has potential applications in investigating therapeutic strategies for GBM by promoting cell death in cancer stem cell populations. -
Apoptosis Inducer
Xanthoangelol is an apoptosis inducer derived from Angelica keiskei, known for its ability to trigger programmed cell death in neuroblastoma and leukemia cells. It also exhibits anti-inflammatory properties by suppressing obesity-related inflammatory responses and demonstrates antibacterial activity. Additionally, Xanthoangelol inhibits monoamine oxidases, contributing to its diverse biological effects, making it suitable for research in cancer therapeutics and inflammatory disease models. -
Apoptosis Inducer
28-Deoxonimbolide is a limonoid derived from Azadirachta indica, functioning as an apoptosis inducer. This compound exhibits significant anticancer activity by inducing apoptotic cell death in HL60 cells through both mitochondrial and death receptor-mediated pathways. Its ability to trigger these mechanisms makes it a valuable tool for research in cancer biology and apoptosis. -
Apoptosis Inducer
Gomisin N, a lignan compound derived from Schisandra chinensis, functions primarily as an apoptosis inducer. It has demonstrated the ability to activate key signaling pathways such as AMPK, Akt, MAPK/ERK, and Nrf2, while also promoting the activation of caspase-3 and PARP-1. Gomisin N exhibits a range of biological activities including anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis effects, and has shown potential in inhibiting proinflammatory cytokines. Additionally, it possesses anti-tumor properties, particularly against cervical and liver cancers, and may offer benefits in the context of Alzheimer’s disease research. -
Apoptosis Inducer
Hellebrigenin is an apoptosis inducer that selectively inhibits the MAPK signaling pathway, including ERK, p38, and JNK, as well as XIAP. It plays a critical role in activating intrinsic apoptosis mechanisms, including mitochondrial membrane potential disruption, activation of the Caspase family, PARP cleavage, and modulation of pro- and anti-apoptotic protein levels. Hellebrigenin also induces DNA double-strand breaks, thereby activating the ATM pathway. This compound is primarily utilized in cancer research, particularly in the study of oral squamous cell carcinoma, liver cancer, and other malignancies, due to its capacity to inhibit tumor cell proliferation and clonogenicity. -
Apoptosis Inducer
α-Santalol, a naturally occurring sesquiterpene, functions as an apoptosis inducer through the activation of caspase-3, leading to enhanced apoptotic processes. This compound has demonstrated the ability to reduce cell viability, induce PARP cleavage, and trigger apoptosis in human prostate cancer cells. Additionally, α-Santalol inhibits the Akt/Survivin signaling pathway to promote cellular death. This reagent is valuable for research focused on prostate cancer and diabetes mellitus. -
Apoptosis Inducer
Polyporenic acid C is a lanostane-type triterpenoid that functions as an apoptosis inducer. Isolated from Poria cocos, this compound activates key apoptotic pathways by cleaving caspase-8, caspase-3, and PARP, while modulating the phosphorylation status of Akt, PTEN, and p53. Additionally, Polyporenic acid C enhances JNK activation and exhibits significant anticancer activity against non-small cell lung cancer. This makes it a valuable reagent for research into cancer therapies and apoptotic mechanisms. -
Apoptosis Inducer
3-O-Methylgallic acid, a potent apoptosis inducer, is an anthocyanin metabolite known for its significant antioxidant properties. It effectively inhibits the proliferation of Caco-2 cells with an IC50 value of 24.1 μM, demonstrating its potential in cancer research. This compound is valuable for studying apoptotic pathways and therapeutic strategies in oncology. -
Apoptosis Inducer
Glaucocalyxin A is an ent-kauranoid diterpene derived from Rabdosia japonica var. This compound acts as an apoptosis inducer by inhibiting the nuclear translocation of Five-zinc finger Glis 1 (GLI1), effectively modulating the PI3K/Akt signaling pathway. Its notable antitumor properties make Glaucocalyxin A a valuable reagent for research in cancer biology, particularly in studies focused on osteosarcoma. -
Apoptosis Inducer
Polygalacin D3 is a triterpenoid saponin extracted from the roots of the balloon flower and acts as an apoptosis inducer. It demonstrates significant biological activity by inhibiting the proliferation of non-small cell lung cancer (NSCLC) cell lines through the blockade of the PI3K/Akt signaling pathway. Additionally, Polygalacin D3 induces cell cycle arrest and apoptosis, making it a valuable reagent for cancer research applications. -
Apoptosis Inducer
Dehydroxy-oridonin-vinyl ester is a potent apoptosis inducer that targets the PI3K/Akt signaling pathway. This compound demonstrates strong anti-proliferative activity against SU-DHL-6 lymphoma cells, with an IC₅₀ value of 0.12 μM. Dehydroxy-oridonin-vinyl ester selectively induces cell apoptosis while not interfering with cell cycle progression, making it a valuable tool for research in cancer therapy, particularly in the study of lymphoma. -
Apoptosis Inducer
BIBU1361 dihydrochloride is an apoptosis inducer that primarily targets pro-survival pathways, including Akt/mTOR and gp130/JAK/STAT3. This compound effectively promotes apoptosis while inhibiting autophagy, leading to a reduction in pro-inflammatory cytokine levels, particularly IL-6. BIBU1361 dihydrochloride is valuable for research applications focused on cancer therapy and the modulation of inflammatory responses. -
Apoptosis Inducer
DCZ3301 is a potent apoptosis inducer that functions as an aryl-guanidino inhibitor. It effectively inhibits cell proliferation, induces G2/M cell cycle arrest, and facilitates apoptosis. By downregulating PI3K protein expression and inhibiting AKT phosphorylation, DCZ3301 targets the PI3K/AKT signaling pathway, making it a valuable reagent for cancer research. -
Apoptosis Inducer
Licoricidin (LCD) is a potent apoptosis inducer derived from Glycyrrhiza uralensis Fisch, demonstrating significant anti-cancer properties. It effectively inhibits SW480 colorectal cancer cells with an IC50 of 7.2 μM by promoting cell cycle arrest, apoptosis, and autophagy, making it a promising candidate for chemoprevention and chemotherapy. Additionally, Licoricidin suppresses lung metastasis through the inhibition of tumor angiogenesis and lymphangiogenesis, while improving the tumor microenvironment. In osteosarcoma models, Licoricidin enhances the cytotoxic effects of gemcitabine by inactivating the Akt and NF-κB signaling pathways. Furthermore, Licoricidin alleviates UVA-induced photoaging by scavenging reactive oxygen species and inhibiting MMP-1 activity, indicating its potential in topical anti-aging formulations. -
Autophagy/Apoptosis Inducer
Autophagy Inducer 7 is an effective modulator of autophagy and apoptosis, primarily targeting the Akt/mTOR signaling pathway. This compound promotes autophagy by inhibiting pathway activity and downregulating associated proteins, leading to a reduction in DNA synthesis and inducing G0-G1 cell cycle arrest. Additionally, Autophagy Inducer 7 has demonstrated the ability to inhibit tumor cell proliferation, making it a valuable tool for research in cancer biology and therapeutic strategies involving autophagy. -
Apoptosis Inducer
Crebanine is an isoquinoline-like alkaloid that acts as an apoptosis inducer through antagonism of the α7-nAChR, exhibiting an IC50 value of 19.1 μM. This compound suppresses cancer cell proliferation, migration, and invasion while triggering a reactive oxygen species (ROS) burst that promotes apoptosis. Additionally, Crebanine modulates critical signaling pathways including AKT/FoxO3a, NF-κB, and MAPK, and demonstrates antioxidant properties in microglia by reducing ROS and lipid peroxidation. With applications in studying hepatocellular carcinoma, cerebral ischemia, and Alzheimer's disease, Crebanine may also ameliorate cognitive deficits and ischemia-reperfusion brain damage in rodent models. -
Apoptosis Inducer
Alphitolic acid, an apoptosis inducer, is a triterpene isolated from Quercus aliena. It functions by inhibiting Akt–NF-κB signaling pathways, promoting apoptosis and autophagy. Additionally, Alphitolic acid exhibits anti-inflammatory properties by down-regulating nitric oxide and TNF-α production. This compound is applicable in cancer and inflammation research. -
Apoptosis Inducer
Tributyrin, a triglyceride variant of butyric acid, functions as a stable proagent that induces apoptosis. Upon diffusion through biological membranes, it is metabolized by intracellular lipases to release butyrate, which exerts significant antiproliferative and pro-apoptotic effects within cells. This compound serves as a valuable reagent for research into cell differentiation and apoptosis pathways. -
Apoptosis Inducer
6-Dehydrogingerdione serves as an apoptosis inducer by enhancing the sensitivity of human hepatoblastoma Hep G2 cells to TRAIL-induced cell death. This compound mediates its effects through the production of reactive oxygen species, which lead to an upregulation of death receptor 5 (DR5). Its ability to modulate apoptotic pathways makes it a valuable tool for research in cancer therapies and cell death mechanisms. -
Apoptosis Inducer
3-O-Acetyloleanolic acid (3AOA) is an oleanolic acid derivative that functions as an apoptosis inducer. It has demonstrated significant anti-cancer properties, promoting cell death in various cancer types, and displays anti-angiogenic activity, inhibiting the formation of new blood vessels. Research applications include studies on cancer therapy and the mechanisms of apoptosis and angiogenesis. -
Apoptosis Inducer
Desacetylcinobufotalin is a natural compound known for its role as an apoptosis inducer. It exhibits significant inhibitory effects on HepG2 cancer cells, with an IC50 value demonstrating potent cytotoxicity. This compound is primarily used in cancer research to explore mechanisms of programmed cell death and therapeutic strategies for hepatic carcinoma. -
Apoptosis Inducer
BMS 310705 (21-Aminoepothilone B) is an apoptosis inducer that targets malignancies, including ovarian, renal, bladder, and lung carcinoma. This compound promotes significant apoptotic activity through a mitochondrial-mediated pathway, making it a valuable tool for cancer research. Its effectiveness in inducing programmed cell death highlights its potential applications in studying tumor biology and developing novel therapeutic strategies. -
Apoptosis Inducer
(S)-(-)-Perillic acid is a terpenoid compound known for its role as an apoptosis inducer. It promotes cell apoptosis and cell cycle arrest while enhancing the levels of key proteins such as Bax, Bcl-2, p21, and caspase-3. This reagent is suitable for research applications related to cancer and infectious diseases, providing valuable insights into therapeutic mechanisms and cellular pathways. -
Apoptosis Inducer
Toddaculin is a natural coumarin known for its role as an apoptosis inducer. It effectively induces differentiation and apoptotic processes in leukemic cells while simultaneously suppressing excessive osteoclast activity. Additionally, Toddaculin promotes osteoblast differentiation and mineralization and demonstrates anti-inflammatory properties, making it a valuable reagent for research in cancer biology and bone metabolism. -
Apoptosis Inducer
2,3-DCPE hydrochloride is an apoptosis inducer that promotes programmed cell death through the downregulation of Bcl-XL expression. This reagent exhibits anti-tumor activity, making it a valuable tool in cancer research, particularly in studies focused on cell survival mechanisms and therapeutic targets for malignancies. -
Apoptosis Inducer
(-)-Epipodophyllotoxin is an apoptosis inducer derived from the American mayapple, Podophyllum peltatum. Exhibiting potent antiproliferative activity, it demonstrates GI50 values of 0.36 and 0.24 μM against HeLa and MCF-7 cancer cell lines, respectively. Additionally, (-)-Epipodophyllotoxin has been shown to inhibit mitotic spindle assembly in vitro, making it a valuable reagent for cancer research and studies involving cell cycle dynamics. -
Apoptosis Inducer
3-Dehydrotrametenolic acid is an apoptosis inducer that functions as a lactate dehydrogenase (LDH) inhibitor. Isolated from the sclerotium of Poria cocos, it has been shown to promote adipocyte differentiation in vitro and to enhance insulin sensitivity in vivo. Additionally, 3-dehydrotrametenolic acid exhibits anticancer properties by inducing apoptosis in cancer cells, making it a valuable compound for research in cancer biology and metabolic disorders. -
Apoptosis Inducer
Lucidenic acid B is a natural compound derived from Ganoderma lucidum that serves as an apoptosis inducer. It stimulates the activation of caspase-9 and caspase-3, leading to the cleavage of PARP in cancer cells. Notably, Lucidenic acid B does not alter the cell cycle profile or increase the number of necrotic cells, making it a valuable reagent for research in cancer biology and apoptosis studies. -
Apoptosis Inducer
Cantrixil, an active enantiomer of TRX-E-002, functions as a potent apoptosis inducer. It elevates phosphorylated c-Jun levels, leading to caspase-mediated apoptosis specifically in ovarian cancer cells. This second-generation super-benzopyran compound demonstrates significant pan anti-cancer activity across a variety of cancer phenotypes, making it a valuable tool for research into cancer therapeutics and mechanisms of cell death. -
Apoptosis Inducer
13'-Carboxy-δ-tocopherol, a metabolite of long-chain vitamin E, serves as an apoptosis inducer by activating caspase-3 and caspase-9, leading to PARP-1 cleavage. This compound demonstrates significant antiproliferative effects in cancer cells by reducing mitochondrial membrane potential and increasing reactive oxygen species (ROS) formation, ultimately driving apoptosis. 13'-Carboxy-δ-tocopherol is valuable in research focused on hepatocellular carcinoma and other cancer types. -
Ferroptosis/Apoptosis Inducer
Lepadin H is a potent ferroptosis and apoptosis inducer, demonstrating significant in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. This compound functions by decreasing the levels of GPX4 and SLC7A11, while enhancing p53 and ACSL4 expression. Lepadin H promotes the generation of lipid hydroperoxides and increases reactive oxygen species (ROS), leading to a reduction in cellular glutathione (GSH) levels and lipid peroxidation. Additionally, it causes G2/M phase cell cycle arrest and inhibits the clonogenic growth and migration of melanoma cells, making it a valuable tool for cancer research. -
Apoptosis Inducer
α-Eleostearic acid is a conjugated linolenic acid that functions as an apoptosis inducer, demonstrating its role in prompting programmed cell death. Additionally, it acts as a ferroptosis inducer, contributing to a unique mechanism of cell death associated with iron metabolism. This compound exhibits notable antioxidant properties and displays antitumor activity, making it a valuable reagent for research in cancer biology and cell death mechanisms. -
Apoptosis Inducer
(-)-Alkannin is a potent apoptosis inducer, extracted from Alkanna tinctoria, and has demonstrated significant anticancer activity. It effectively arrests the cell cycle and triggers apoptotic processes in various cancer cell lines. Additionally, (-)-Alkannin contributes to the reduction of hepatic inflammation through modulation of the Rho-kinase pathway, making it a valuable tool for research in cancer biology and inflammation studies.
