Catalog No.
Product Name
Application
Product Information
Citations
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14-3-3 protein Inhibitor
Difopein, dimeric version of R18 peptide that binds to 14.3.3 proteins with high affinity.- William J Stone, .et al. , J Neurochem, 2025, Sep;169(9):e70228 PMID: 40931680
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Apoptosis inducer
LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.- Yingzheng Xu, .et al. , JCI Insight, 2024, Jun 13:e174746 PMID: 38869957
- Ting TC, .et al. , Cell Rep, 2019, Nov 5;29(6):1499-1510.e6 PMID: 31693891
- Ting Han, .et al. , Science, 2017, Apr 28;356(6336). pii: eaal3755 PMID: 28302793
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Stat3 inhibitor & Apoptosis inducer
Homoharringtonine is a cephalotaxine alkaloid which inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes. -
Apoptosis inducer
IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC). -
Apoptosis inducer
Episilvestrol is a derivative of Silvestrol, which can induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM). - Cinchonine prevents High-Fat-Diet-Induced Obesity through downregulation of Adipogenesis and Adipose inflammation.
- Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.
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broad-spectrum antimicrobial
Taurolidine is a broad-spectrum antimicrobial for the prevention of central venous catheter-related infections. Taurolidine has a direct and selective antineoplastic effect on brain tumor cells by the induction of apoptosis. - Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.
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antiarthritic drugs
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs. -
insecticidal and anticancer
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. -
Apoptosis Inducer
Thonningianin A is an ellagitannin that serves as an apoptosis inducer. Isolated from the methanolic extract of the African medicinal herb Thonningia sanguinea, this compound demonstrates significant antioxidant properties, including radical scavenging, anti-superoxide formation, and metal chelation. Thonningianin A is recognized for its potential anti-cancer activities, making it relevant for research in oncology and cellular signaling pathways related to apoptosis. -
Apoptosis Inducer
Hirsutine, an indole alkaloid derived from Uncaria rhynchophylla, serves as an apoptosis inducer with notable anti-cancer properties. It effectively triggers apoptotic pathways while demonstrating significant inhibitory effects against Dengue virus, all with low cytotoxicity. This compound is valuable for research in cancer biology and virology, enabling studies on apoptotic mechanisms and antiviral strategies. -
Apoptosis Inducer
Ganoderic Acid D is a tetracyclic triterpenoid derived from Ganoderma lucidum, known for its role as an apoptosis inducer. This compound facilitates the upregulation of SIRT3 protein expression, leading to enhanced deacetylation of cyclophilin D (CypD). Ganoderic Acid D effectively disrupts energy metabolism in colon cancer cells by inhibiting glucose uptake, lactate production, and the synthesis of pyruvate and acetyl-CoA. Additionally, it demonstrates potent apoptotic effects in HeLa human cervical carcinoma cells, making it a valuable reagent for cancer research applications. -
Apoptosis Inducer/Autophagy Inhibitor
Kumatakenin is a potent apoptosis inducer and autophagy inhibitor that targets ATG5 with a Kd value of 2.94 μM. It effectively enhances the activity of caspases 3, 8, and 9, leading to caspase-dependent apoptosis in ovarian cancer cells while modulating chemokines and pro-oncogenic factors. Kumatakenin also reduces M2 macrophage polarization, inhibits tumor progression in esophageal cancer by targeting FASN, and interacts with Eno3 to mitigate ferroptosis and alleviate intestinal inflammation. This compound is valuable for studies in ovarian cancer, esophageal cancer, depression, and colitis research. -
Apoptosis Inducer
Mepazine is a selective inhibitor of MALT1 protease, demonstrating IC50 values of 0.83 and 0.42 μM for full-length GSTMALT1 and the GSTMALT1 325-760 fragment, respectively. This compound effectively enhances apoptosis and reduces the viability of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cells. Mepazine serves as a valuable tool for investigating apoptosis mechanisms and potential therapeutic applications in cancer research. -
Apoptosis Inducer
Medicarpin is a flavonoid derived from Medicago sativa that functions as an apoptosis inducer. It has been shown to effectively induce apoptosis and counteract multidrug resistance in leukemia P388 cells by modulating the P-glycoprotein-mediated efflux of chemotherapeutic agents. This compound serves as a valuable tool for research into cancer treatment and the mechanisms underlying drug resistance. -
Apoptosis Inducer
Bromelain is an apoptosis inducer derived from pineapple stem that exhibits anti-inflammatory properties. It functions by down-regulating plasma kininogen, inhibiting Prostaglandin E2 expression, and degrading advanced glycation end product receptors, alongside modulating angiogenic biomarkers and displaying antioxidant activity in the COX pathway. Bromelain demonstrates fibrinolytic, antiedematous, and antithrombotic effects, while also showcasing potential anticancer activities through the promotion of apoptotic cell death, making it a valuable tool for cancer research and inflammation studies. -
Apoptosis Inducer
ATH686 is a potent apoptosis inducer that selectively inhibits the mutant FLT3 protein kinase. By targeting ATP-binding sites, ATH686 effectively disrupts the proliferation of cells harboring FLT3 mutations, leading to apoptosis and cell cycle arrest. This compound is particularly relevant for research applications in the study of leukemic cell signaling and therapeutic interventions for FLT3-mutant leukemias. -
Apoptosis Inducer
Pinoresinol is a lignan that acts as an apoptosis inducer through the sensitization of cancer cells. It has been shown to enhance the susceptibility of these cells to TNF-related apoptosis-inducing ligand (TRAIL), thereby promoting apoptotic cell death. This compound is widely used in cancer research, particularly in studies aimed at elucidating mechanisms of TRAIL-induced apoptosis and developing potential therapeutic strategies. -
Apoptosis Inducer
Cycloartenol, a phytosterol compound, functions as an apoptosis inducer, exerting significant influence on cellular processes. It has been shown to inhibit glioma cell migration and suppress p38 MAP kinase phosphorylation, making it valuable for cancer research. Additionally, cycloartenol exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, and anti-tumor properties, as well as potential applications in neurodegenerative disease studies. This compound also contributes to essential processes in plant growth and development. -
Apoptosis Inducer
Pulsatilla saponin D is an apoptosis inducer derived from the root of Pulsatilla chinensis. It exhibits potent anti-tumor activity by promoting programmed cell death in cancer cells. This compound is primarily used in research applications focused on understanding the mechanisms of apoptosis and evaluating potential therapeutic strategies in oncology. -
Apoptosis Inducer
Physalin F is a secosteroid that acts as an apoptosis inducer. It effectively induces apoptosis in peripheral blood mononuclear cells (PBMCs), leading to a reduction in spontaneous proliferation and cytokine production associated with Human T-lymphotropic virus type 1 (HTLV-1) infection. This compound demonstrates significant anti-inflammatory and immunomodulatory properties, making it valuable for research in viral pathogenesis and cellular immune responses. -
Apoptosis Inducer
Mepazine hydrochloride is a potent apoptosis inducer that selectively inhibits MALT1 protease, exhibiting IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. This compound effectively enhances apoptosis in ABC-DLBCL cells, making it a valuable tool for research into apoptotic mechanisms and therapeutic strategies in cancer biology. -
Apoptosis Inducer
SW106065 is an apoptosis inducer that targets malignant peripheral nerve sheath tumors (MPNST). It effectively inhibits ATP consumption in sMPNST models with an EC50 of 1 µM. This compound is a valuable tool for investigating the molecular mechanisms of MPNST and evaluating potential therapeutic strategies. -
Apoptosis Inducer
Furanodienone is an apoptosis inducer derived from the bioactive constituents of Rhizoma Curcumae. It has been shown to effectively promote programmed cell death in various cell types, making it a candidate for research in cancer therapy and related fields. Its ability to modulate apoptotic pathways highlights its potential in studies exploring therapeutic interventions and cancer treatment strategies. -
Apoptosis Inducer
2'-Aminoacetophenone is an apoptosis inducer that functions primarily by disrupting mitochondrial activity through the induction of oxidative stress. This compound has demonstrated efficacy in regulating autophagy by inhibiting the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR. Additionally, it serves as a respiratory biomarker for detecting Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients, providing valuable insights into disease mechanisms. Its ability to induce apoptosis signals also contributes to its utility in investigating skeletal muscle dysfunction in murine models. -
Apoptosis Inducer
(E)-Flavokawain A is a chalcone derived from Kava that functions as an apoptosis inducer. It has demonstrated anticarcinogenic properties by inducing apoptosis in bladder cancer cells through a Bax protein-dependent and mitochondria-dependent pathway. Additionally, (E)-Flavokawain A has been shown to suppress tumor growth in murine models, making it a valuable compound for cancer research and therapeutic studies. -
Apoptosis Inducer
7,8-Dihydroneopterin is an apoptosis inducer that enhances the expression of inducible nitric oxide synthase (iNOS) in astrocytes and neurons. This compound plays a significant role in the study of neurodegenerative diseases by promoting cellular apoptosis. Its biological activity provides valuable insights into mechanisms underlying neuroinflammation and neurodegeneration. -
Apoptosis Inducer/Insecticide
Dihydrorotenone is an irreversible inhibitor of mitochondrial complex I and serves as an apoptosis inducer. It demonstrates significant cytotoxicity to human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. Dihydrorotenone's insecticidal properties position it as a valuable tool in studies on neurodegenerative diseases, such as Parkinson's disease, as well as in safety assessments of natural pesticides and cancer chemoprevention research. -
Apoptosis Inducer
Prostaglandin A2 (PGA2) is a cyclopentenone prostaglandin that functions as an apoptosis inducer by activating caspase pathways and modulating the p53 signaling pathway. It also activates ERK2 and JNK1/SAPK pathways, contributing to its role in cell death and differentiation. Prostaglandin A2 exhibits antiviral properties against HSV-1 and demonstrates anti-tumor effects, making it relevant in research applications related to colorectal cancer, breast carcinoma, and herpetic keratitis. -
Apoptosis Inducer
Kahweol is a compound derived from Coffea arabica, functioning primarily as an apoptosis inducer. It exhibits anti-inflammatory, anti-angiogenic, and anti-cancer properties. Kahweol activates AMP-activated protein kinase (AMPK), leading to inhibition of adipogenesis and promotion of glucose uptake. Its biological activities make it valuable for research into cancer biology and metabolic disorders. -
Apoptosis Inducer
Ingenol 3,20-dibenzoate is a selective agonist of specific protein kinase C (PKC) isoforms, primarily targeting nPKC-delta, -epsilon, -theta, and PKC-mu. This compound induces morphologically characteristic apoptosis through the de novo synthesis of macromolecules and facilitates the translocation of these PKC isoforms from the cytosolic to the particulate fraction. Additionally, Ingenol 3,20-dibenzoate enhances interferon-gamma production and promotes the degranulation of natural killer (NK) cells, particularly in the context of non-small cell lung cancer (NSCLC) cell stimulation. Its applications are valuable in research focused on apoptosis and immune response modulation. -
Apoptosis Inducer
Bixin is a carotenoid derived from the seeds of Bixa orellana that acts as an apoptosis inducer. It has been shown to effectively induce cell death in cancer cells while also exhibiting notable anti-inflammatory, anti-tumor, and antioxidant properties. Additionally, Bixin treatment has demonstrated a protective effect on cardiac function by reducing fibrosis, inflammation, and the generation of reactive oxygen species (ROS), making it a valuable compound for research in cancer and cardiovascular diseases. -
Apoptosis Inducer
Euphorbia Factor L2 is a lathyrane diterpenoid that acts as an apoptosis inducer. Isolated from the seeds of Euphorbia lathyris L., it demonstrates potent cytotoxicity and triggers apoptosis through the mitochondrial pathway. This compound is a valuable tool for cancer research, providing insights into mechanisms of cell death and potential therapeutic applications in oncology. -
Apoptosis Inducer
Falcarindiol is an orally active polyacetylenic oxylipin that functions as an apoptosis inducer by activating PPARγ and enhancing the expression of the cholesterol transporter ABCA1 in cells. This compound exhibits significant biological activities, including anti-inflammatory, antifungal, anticancer, and antidiabetic effects. Additionally, as a click chemistry reagent, Falcarindiol contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various research applications. -
Apoptosis Inducer
Ethylene dimethanesulfonate is a pro-apoptotic compound that functions as a mild alkylating agent. It selectively induces apoptosis in lymphocytes, making it a valuable tool for studying programmed cell death. This reagent is useful in research applications involving cancer biology, immunology, and cellular stress response mechanisms. -
Apoptosis Inducer
Delphinidin 3-rutinoside chloride is an active anthocyanin that functions as an apoptosis inducer, primarily targeting B cell chronic lymphocytic leukemia (B CLL). This compound demonstrates pro-apoptotic effects by promoting cell death in B CLL cells. Additionally, it exhibits phytoestrogen activity through its binding affinity for estrogen receptor beta (ERβ), with an IC50 value of 2.3 μM, making it a valuable tool for cancer research and apoptosis studies. -
Apoptosis Inducer
Leachianone A is a potent apoptosis inducer derived from Radix Sophorae. This compound exhibits notable anti-malarial, anti-inflammatory, and cytotoxic properties. Leachianone A effectively triggers apoptosis through both extrinsic and intrinsic pathways, making it a valuable reagent for research in therapeutic applications aimed at programmed cell death and disease modulation. -
Apoptosis Inducer
Polygalacin D (PGD) is an apoptosis inducer derived from Platycodon grandiflorum, exhibiting significant anticancer and anti-proliferative effects. It effectively downregulates inhibitor of apoptosis (IAP) proteins, including survivin, cIAP-1, and cIAP-2, while inhibiting the PI3K/Akt signaling pathway through the dephosphorylation of GSK3β and Akt, along with reduced expression of PI3K. PGD serves as a valuable reagent for research in cancer biology and therapeutic investigations targeting apoptosis mechanisms. -
Apoptosis Inducer
δ-Cadinene is a sesquiterpene primarily known for its role as an apoptosis inducer. It exhibits significant antiproliferative and pro-apoptotic effects specifically in human ovarian cancer (OVCAR-3) cells. Additionally, δ-Cadinene demonstrates broad-spectrum bioactivity, including trichomonacidal, antimicrobial, antifungal, and anticancer properties, making it a valuable compound for various research applications in cancer biology and infectious disease studies. -
Apoptosis Inducer
(E/Z)-E64FC26 is a mixture of E-E64FC26 and Z-E64FC26, functioning as a potent pan-inhibitor of the protein disulfide isomerase (PDI) family. It exhibits significant biological activity with IC50 values of 1.9 μM for PDIA1, 20.9 μM for PDIA3, 25.9 μM for PDIA4, 16.3 μM for TXNDC5, and 25.4 μM for PDIA6. This compound is particularly valuable in research related to apoptosis induction and has demonstrated anti-myeloma properties. -
Apoptosis Inducer
EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) specifically designed to target the triple mutant EGFRL858R/T790M/C797S, exhibiting an IC50 of 18 nM. This compound effectively suppresses EGFR phosphorylation, thereby inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. It serves as a valuable tool for research into cancer therapies focused on overcoming resistance in EGFR-mutated tumor cells. -
Apoptosis Inducer
Carubicin hydrochloride is an apoptosis inducer that targets cancer cell proliferation. Derived from microbial sources, it effectively inhibits the growth of VHL-defective clear cell renal cell carcinoma (CCRCC) cells. Notably, carubicin hydrochloride induces apoptosis through mechanisms that are independent of p53 and hypoxia-inducible factor HIF2. This compound holds significant potential for research applications in cancer biology.
