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GPCR/G Protein
Free Fatty Acid Receptor (FFAR)

Free Fatty Acid Receptor (FFAR)

Catalog No.

Product Name

Application

Product Information

Product Citation

A11018

TAK-875 (Fasiglifam)

GPR agonist

TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.

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- Ying Liu, .et al. , Nucleic Acids Res, 2018, Oct 12; 46(18): 9864-9874 PMID: 30219861
- Deborah A. Goldspink, .et al. , Mol Metab, 2018, Jan; 7: 90-101 PMID: 29167062
- Hodaka Yamada, .et al. , Sci Rep, 2016, 6: 25912 PMID: 27180622
A13468

AMG 837 calcium hydrate

GPR40/FFA1 agonist

AMG-837 calcium hydrate is a potent, orally bioavailable GPR40 agonist.

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A14542

GSK137647A

FFA4/GPR120 agonist

GSK137647A is a selective FFA4 agonist, with pEC50 of 6.3, 6.2, and 6.1 for human, Mouse and Rat FFA4, respectively.

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A18335

TUG-891

FFA4/GPR120 agonist

TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism.

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