Melatonin Receptors

Melatonin is a endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2.

Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ?? 8.55 pM)and MT2 (20.1 ?? 9.25 pM)receptors and selectivity over the MT3 receptor.

Tasimelteon is a melatonin MT1 and MT2 receptor agonist.