Apoptosis

GSK1059865 is a potent orexin 1 receptor antagonist.

Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.

MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists.

ACT-335827 is a selective orexin receptor 1 antagonist.

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.

A potent and selective Orexin2 receptor agonist.

IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.