Apoptosis

GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.

BDA-366 selectively inhibits BCL2, converting it to a cell death inducer.

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).

CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.

AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.