DHFR

NSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM.

Aminopterin is an antineoplastic drug. It works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase.

Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.

Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.