Metabolism

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1).

TRC051384 is an inducer of heat shock protein Hsp70.

FIN56 is a specific inducer of ferroptosis.

CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.

Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP).