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Immunology & Inflammation

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  1. A13826
    PTC-209

    BMI-1 inhibitor

    PTC-209 is a novel potent and selective BMI-1 inhibitor, targeting the BMI-1 self-renewal machinery with an IC50 of ~0.5 μM.
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  2. A15453
    PRT 4165

    Bmi1/Ring1A inhibitor

    PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). It prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha.
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  3. A16812
    PTC-028

    BMI-1 inhibitor

    PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification
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