Salt-inducible Kinase (SIK)

ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L.

YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.