GABA Receptors

Lorediplon is a novel non-benzodiazepine, hypnotic drug acting as a GABAA receptor modulator,

Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner.

Basmisanil is a highly selective GABAAα5 negative allosteric modulator.

NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors.

SSD114 hydrochloride is a novel GABAB receptor positive allosteric modulator.

SJM-3 is a positive allosteric modulator of different isoforms of the GABAA receptor. SJM-3 binds at the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.