Wnt

CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.

GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.

IWP-4 is a novel potent inhibitor of Wnt/β-catenin signaling.

Adavivint (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.

NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21?nM.