Potassium Channels

GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2).

KB130015 is a novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages, but activating them at low voltages.

ICA-110381 is a KV7.2/7.3 activator with EC50 of 0.38 uM.

NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 uM).

ML402 is a selective TREK-1 activator.

VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 ?M and 5.2 ?M for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel.

Levcromakalim ((-)-Cromakalim) is an ATP-sensitive K+ channel (KATP) activator.