E1 activating

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  1. UWE1 ubiquitin ligase inhibitor

    BI-8622 is a specific inhibitor of the HUWE1 ubiquitin ligase.
  2. HUWE1 inhibitor

    BI-8626 is a specific inhibitor of the HUWE1 ubiquitin ligase with an IC50 of 0.9 μM.
  3. Teslexivir (BTA074; AP 611074) is a topical antiviral agent that is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an interaction that is a necessary step for Human Papilloma Virus (HPV) 6 and 11 DNA replication and thus viral production.
  4. SUMO inhibitor

    TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.

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