p97

NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening.

Dbeq is a selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 uM).

CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models .

ML241 is a potent and selective inhibitors of p97 ATPase. ML241 inhibit p97 ATPase with IC(50) values of 100 nM.

ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.