GPCR19

SB756050 is a selective TGR5 agonist currently in phase 1clinical trials for the treatment of type 2 diabetes.

TGR5 Receptor Agonist is a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).

Sodium deoxycholate is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.